Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 4/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | ROS1 | P08922 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12879987 | 1.00 | TACR3 (0.35) | TACR3MGAT2P2RX7PDE4DCYP11B2 | |
| SCHEMBL15106978 | 0.93 | MGAT2 (0.36) | MGAT2PDE4D | |
| SCHEMBL12880010 | 0.84 | MGAT2 (0.33) | TACR3MGAT2P2RX7PIM1 | |
| SCHEMBL12879594 | 0.82 | MAPK1 (0.35) | PDE4D | |
| SCHEMBL8058110 | 0.80 | PDE4D (0.42) | PDE4D | |
| SCHEMBL8046538 | 0.80 | MAPK1 (0.32) | — | |
| SCHEMBL8058388 | 0.79 | PDE4D (0.33) | PDE4D | |
| SCHEMBL1202943 | 0.79 | MGAT2 (0.36) | TACR3MGAT2P2RX7 | |
| SCHEMBL8052339 | 0.79 | TNKS (0.39) | PDE4D | |
| SCHEMBL15106979 | 0.79 | EHMT2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050236-A1 | NOVEL PIPERAZINO-DIHYDROTHIENOPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |