Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GLS | O94925 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8585021 | 0.91 | HPGD (0.49) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6380649 | 0.81 | HPGD (0.54) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29530672 | 0.77 | RAB9A (0.65) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3642366 | 0.77 | RAB9A (0.65) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL25991266 | 0.76 | HPGD (0.61) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2743018 | 0.76 | HPGD (0.61) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8862940 | 0.74 | GAA (0.60) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8862856 | 0.74 | GAA (0.60) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7519591 | 0.74 | GAA (0.60) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8862746 | 0.74 | GAA (0.60) | HPGDNPSR1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136601-A | ADJUSTED NUCLEOTIDE SEQUENCES WHICH CAN BE UTILIZED FOR THE GENERATION OF PREFERENTIAL MUTATION | EPOCH PHARMACEUTICALS, INC. (US) | 2000-10-24 | — | — | US | disclosed |
| US-6072046-A | SELECTIVELY FORM TRIPLEXES WITH A COMPLEMENTARY TARGET SEQUENCE IN DOUBLE-STRANDED DNA AND EFFICIENTLY CROSSLINK WITH BOTH STRANDS; THERAPEUTICS, DIAGNOSTICS, AND GENETIC PROBES | EPOCH PHARMACEUTICALS, INC. (US) | 2000-06-06 | — | — | US | disclosed |
| WO-2000012523-A1 | DIAZIRIDINYL-ARYL AND BIS-[DI(CHLOROETHYL)AMINO]-ARYL OLIGONUCLEOTIDE CONJUGATES AND REAGENTS FOR MAKING THE SAME | EPOCH PHARMACEUTICALS, INC. (US) | 2000-03-09 | — | — | WO | disclosed |
| US-5935830-A | SITE-DIRECTED MUTAGENESIS BY FORMING TRIPLE HELIX WITH DOUBLE-STRANDED DNA AND OLIGONUCLEOTIDE WITH ELECTROPHILIC GROUP, ELECTROPHILIC GROUP CAUSES MODIFICATION OF DNA NUCLEOTIDE, THEN REPLICATION CAUSES MUTATION | EPOCH PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |
| US-5746997-A | Radiohalogenation of oligonucleotides via trialkylstannylaryl conjugates | EPOCH PHARMACEUTICALS, INC. (US) | 1998-05-05 | — | — | US | disclosed |