Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8074878 | 0.82 | KMT2A (0.41) | TSHRALDH1A1MAPK1MAPTPOLB | |
| SCHEMBL8068418 | 0.79 | MEN1 (0.41) | TP53ALDH1A1MAPTPOLBLMNA | |
| SCHEMBL8068449 | 0.79 | ATM (0.38) | TSHRALDH1A1MAPK1MAPTPOLB | |
| SCHEMBL8069911 | 0.75 | F10 (0.40) | TSHRLMNASMN1; SMN2F10PLA2G2A | |
| SCHEMBL8069913 | 0.74 | PLA2G2A (0.37) | LMNAF10PLA2G2A | |
| SCHEMBL17625298 | 0.73 | F10 (0.58) | TSHRALDH1A1MAPK1MAPTPOLB | |
| SCHEMBL182493 | 0.71 | MAPT (0.62) | TSHRALDH1A1MAPK1MAPTPOLB | |
| SCHEMBL9098048 | 0.71 | MAPT (0.55) | TSHRALDH1A1MAPK1MAPTPOLB | |
| SCHEMBL182200 | 0.71 | MAPK1 (0.52) | TSHRALDH1A1MAPK1MAPTPOLB | |
| SCHEMBL14019802 | 0.71 | TSHR (0.54) | TSHRALDH1A1MAPK1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0803501-B1 | Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors | SUMITOMO PHARMA (JP) | 2000-07-05 | — | — | EP | disclosed |
| EP-0803501-A1 | Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-29 | — | — | EP | disclosed |