Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.74 |
| ▸ | RAB9A | P51151 | 7/20 | 0.74 |
| ▸ | NPC1 | O15118 | 6/20 | 0.74 |
| ▸ | MAOB | P27338 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.72 |
| ▸ | RELA | Q04206 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059586 | 1.00 | MAPT (0.74) | MAPTRAB9ANPC1MAOBKMT2A | |
| SCHEMBL6756826 | 0.88 | MAPT (0.71) | MAPTRAB9ANPC1MAOBKMT2A | |
| SCHEMBL8058647 | 0.87 | MAPT (0.62) | MAPTRAB9ANPC1MAOBKMT2A | |
| SCHEMBL8058649 | 0.87 | MAPT (0.62) | MAPTRAB9ANPC1MAOBKMT2A | |
| SCHEMBL6754395 | 0.86 | MAPT (0.67) | MAPTRAB9ANPC1MAOBKMT2A | |
| SCHEMBL6754390 | 0.86 | MAPT (0.67) | MAPTRAB9ANPC1MAOBKMT2A | |
| SCHEMBL6754393 | 0.86 | MAPT (0.67) | MAPTRAB9ANPC1MAOBKMT2A | |
| SCHEMBL6755690 | 0.86 | MAPT (0.69) | MAPTRAB9ANPC1MAOBKMT2A | |
| SCHEMBL4280503 | 0.86 | RAB9A (1.00) | MAPTRAB9ANPC1MAOBKMT2A | |
| SCHEMBL4280508 | 0.86 | RAB9A (1.00) | MAPTRAB9ANPC1MAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |