Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 1/20 | 0.58 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651909 | 0.85 | TAAR1 (0.44) | OGG1KMT2AALDH1A1MAPTHTR2A | |
| SCHEMBL21394757 | 0.85 | OGG1 (0.55) | OGG1GRM5PNMTKMT2AL3MBTL1 | |
| Hydrazine SCHEMBL28120133 | 0.84 | OGG1 (0.58) | OGG1GRM5PNMTKMT2AL3MBTL1 | |
| SCHEMBL105734 | 0.83 | OGG1 (0.57) | OGG1GRM5KMT2AL3MBTL1SLC6A4 | |
| Chloromethane SCHEMBL27541396 | 0.82 | OGG1 (0.56) | OGG1GRM5KMT2AL3MBTL1SLC6A4 | |
| SCHEMBL10451483 | 0.82 | OGG1 (0.56) | OGG1GRM5PNMTKMT2AL3MBTL1 | |
| SCHEMBL10359842 | 0.80 | OGG1 (0.58) | OGG1GRM5KMT2AL3MBTL1SLC6A4 | |
| SCHEMBL17032600 | 0.80 | OGG1 (0.54) | OGG1GRM5PNMTKMT2AL3MBTL1 | |
| SCHEMBL11335792 | 0.80 | OGG1 (0.54) | OGG1GRM5PNMTKMT2AL3MBTL1 | |
| SCHEMBL3160383 | 0.80 | OGG1 (0.54) | OGG1GRM5PNMTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3433234-B1 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2000012522-A1 | MACROLIDE LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2000-03-09 | — | — | WO | disclosed |
| US-6020521-A | Macrolide LHRH antagonists | ABBOTT LABORATORIES (US) | 2000-02-01 | — | — | US | disclosed |
| US-4119729-A | TREATMENT OF HYPERTENSION | MEAD JOHNSON & COMPANY (US) | 1978-10-10 | — | — | US | disclosed |
| US-4067904-A | ANTIARRHYTHMIA, HYPOTENSIVE | MEAD JOHNSON & COMPANY (US) | 1978-01-10 | — | — | US | disclosed |