Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 6/20 | 0.53 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GGH | Q92820 | 1/20 | 0.46 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5053274 | 0.86 | GGH (0.49) | FOLH1NAALAD2CYP1A2GGHGRM3 | |
| SCHEMBL7608707 | 0.83 | FOLH1 (0.44) | FOLH1NAALAD2CYP1A2GGHGRM3 | |
| SCHEMBL7605307 | 0.82 | GABRP (0.47) | FOLH1NAALAD2CYP1A2GGHGRM3 | |
| SCHEMBL8048482 | 0.80 | FOLH1 (0.42) | FOLH1NAALAD2CYP1A2GGHGRM3 | |
| SCHEMBL8469639 | 0.80 | CYP1A2 (0.50) | FOLH1NAALAD2CYP1A2GGHGRM3 | |
| SCHEMBL9296105 | 0.79 | TDP1 (0.54) | FOLH1NAALAD2 | |
| SCHEMBL7609969 | 0.78 | FOLH1 (0.40) | FOLH1NAALAD2CYP1A2GGHGRM3 | |
| SCHEMBL22985 | 0.78 | FOLH1 (0.55) | FOLH1NAALAD2CYP1A2GGHGRM3 | |
| SCHEMBL8063538 | 0.77 | FOLH1 (0.39) | FOLH1NAALAD2CYP1A2GGHGRM3 | |
| SCHEMBL7607505 | 0.77 | GGH (0.51) | FOLH1CYP1A2GGH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005348-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-06-07 | — | — | EP | disclosed |
| WO-1998013046-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | disclosed |