Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610568 | 0.85 | IDO1 (0.42) | IDO1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL7610440 | 0.78 | PTPN1 (0.46) | KDM4EGAA | |
| SCHEMBL7605830 | 0.77 | IDO1 (0.41) | IDO1DRD2DRD3KDM4EHSD17B10 | |
| SCHEMBL7607603 | 0.76 | IDO1 (0.40) | IDO1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL7609376 | 0.75 | ACP3 (0.43) | KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL7610417 | 0.75 | CFTR (0.37) | IDO1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL7603971 | 0.75 | SLC6A2 (0.39) | KDM4EHSD17B10MAPTALDH1A1MAPK1 | |
| SCHEMBL7920074 | 0.74 | DRD2 (0.39) | IDO1DRD2DRD3HPGDGAA | |
| SCHEMBL15641062 | 0.71 | IDO1 (0.48) | IDO1IL4I1KDM4EHSD17B10HPGD | |
| SCHEMBL7607399 | 0.71 | PTPN1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005348-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-06-07 | — | — | EP | disclosed |
| WO-1998013046-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | disclosed |