⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768267 | 0.70 | — | — | |
| SCHEMBL2442544 | 0.70 | LMNA (0.38) | — | |
| SCHEMBL10893086 | 0.65 | — | — | |
| SCHEMBL8060090 | 0.65 | — | — | |
| SCHEMBL10628940 | 0.64 | — | — | |
| SCHEMBL1358962 | 0.64 | — | — | |
| SCHEMBL21307116 | 0.63 | — | — | |
| SCHEMBL6717791 | 0.61 | — | — | |
| Ammonia Solution, Strong SCHEMBL9300246 | 0.61 | — | — | |
| Hydrochloric Acid SCHEMBL20295189 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230115675-A1 | METHODS OF TREATING CANCER | BROAD INST INC (US) | 2023-04-13 | — | — | US | disclosed |
| CN-115917324-A | Methods of treating cancer | 布罗德研究所有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4111202-A1 | METHODS OF TREATING CANCER | The Broad Institute Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| US-11092602-B2 | Methods and compositions relating to proteasome inhibitor resistance | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2021-08-17 | — | — | US | disclosed |
| US-20180353445-A1 | METHODS AND COMPOSITIONS RELATING TO PROTEASOME INHIBITOR RESISTANCE | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH | 2018-12-13 | — | — | US | disclosed |
| US-20180306796-A1 | METHODS AND COMPOSITIONS RELATING TO PROTEASOME INHIBITOR RESISTANCE | HOWARD HUGHES MEDICAL INSTITUTE | 2018-10-25 | — | — | US | disclosed |
| WO-2017064241-A1 | COMBINATION COMPRISING AN AMINOTHIOLESTER COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND A COMPOUND ABLE TO INCREASE THE H2O2 LEVEL IN CANCER CELLS OF A SUBJECT | ADVANCED BIODESIGN (FR) | 2017-04-20 | — | — | WO | disclosed |
| WO-2017064247-A1 | AMINOTHIOLESTER COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, FOR USE IN THE TREATMENT OF CANCER | ADVANCED BIODESIGN (FR) | 2017-04-20 | — | — | WO | disclosed |
| WO-2017007858-A1 | METHODS AND COMPOSITIONS RELATING TO PROTEASOME INHIBITOR RESISTANCE | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-01-12 | — | — | WO | disclosed |
| EP-2958592-A1 | METHODS OF TREATING CANCER AND PREVENTING DRUG RESISTANCE | F. Hoffmann-La Roche AG (CH) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014128235-A1 | METHODS OF TREATING CANCER AND PREVENTING DRUG RESISTANCE | F. HOFFMANN-LA ROCHE AG (CH) | 2014-08-28 | — | — | WO | disclosed |
| US-6028114-A | Use of aminothiolester derivatives in pharmaceutics | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2000-02-22 | — | — | US | disclosed |