Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.67 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.67 |
| ▸ | MTOR | P42345 | 5/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
| ▸ | JAK1 | P23458 | 1/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.67 |
| ▸ | JAK3 | P52333 | 1/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654994 | 0.92 | PIK3CA (0.81) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL8077111 | 0.82 | PIK3CA (0.54) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL20690791 | 0.81 | PIK3CA (0.74) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| Vs-5584 SCHEMBL29376859 | 0.81 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| Vs-5584 SCHEMBL539098 | 0.81 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL3653208 | 0.81 | PIK3CA (0.67) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL14731779 | 0.81 | PIK3CA (0.67) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL7902199 | 0.79 | PIK3CA (0.65) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL3716913 | 0.79 | PIK3CA (0.64) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL7895959 | 0.79 | PIK3CA (0.64) | PIK3CAPIK3R1MTORPIK3CDJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009045175-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |