Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.58 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060437 | 1.00 | TRPA1 (0.58) | TRPA1TRPM8EGFRKDM4EHSD17B10 | |
| SCHEMBL8065940 | 0.90 | GRIK1 (0.62) | TRPA1TRPM8EGFRMEN1ALDH1A1 | |
| SCHEMBL8065942 | 0.90 | GRIK1 (0.62) | TRPA1TRPM8EGFRMEN1ALDH1A1 | |
| SCHEMBL8060511 | 0.88 | TRPA1 (0.76) | TRPA1TRPM8EGFRKDM4EHSD17B10 | |
| SCHEMBL8060509 | 0.88 | TRPA1 (0.76) | TRPA1TRPM8EGFRKDM4EHSD17B10 | |
| SCHEMBL8065330 | 0.85 | TRPA1 (0.58) | TRPA1TRPM8EGFRKDM4EHSD17B10 | |
| SCHEMBL8065329 | 0.85 | TRPA1 (0.58) | TRPA1TRPM8EGFRKDM4EHSD17B10 | |
| SCHEMBL8060362 | 0.85 | TRPA1 (0.58) | TRPA1TRPM8EGFRKDM4EHSD17B10 | |
| SCHEMBL8060365 | 0.85 | TRPA1 (0.58) | TRPA1TRPM8EGFRKDM4EHSD17B10 | |
| SCHEMBL8047998 | 0.85 | MAOB (0.60) | TRPA1TRPM8EGFRKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |