Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044111 | 1.00 | KMT2A (0.60) | KMT2AMEN1ATMHTTALDH1A1 | |
| SCHEMBL27795750 | 1.00 | KMT2A (0.60) | KMT2AMEN1ATMHTTALDH1A1 | |
| SCHEMBL12946361 | 0.86 | KMT2A (0.57) | KMT2AMEN1ATMHTTALDH1A1 | |
| SCHEMBL8045931 | 0.86 | KMT2A (0.60) | KMT2AMEN1ATMHTTALDH1A1 | |
| SCHEMBL8070518 | 0.84 | KMT2A (0.44) | KMT2AMEN1ATMHTTALDH1A1 | |
| SCHEMBL8068964 | 0.84 | HTT (0.52) | KMT2AMEN1ATMHTTALDH1A1 | |
| SCHEMBL12920954 | 0.79 | KMT2A (0.70) | KMT2AMEN1ATMHTTALDH1A1 | |
| SCHEMBL3923891 | 0.77 | KMT2A (0.63) | KMT2AMEN1ATMHTTALDH1A1 | |
| SCHEMBL13082765 | 0.76 | KMT2A (0.52) | KMT2AMEN1ATMALDH1A1KDM4E | |
| SCHEMBL12920962 | 0.74 | KMT2A (0.57) | KMT2AMEN1ATMHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101878202-A | Gamma secretase modulators | SCHERING CORP | 2010-11-03 | — | — | CN | disclosed |
| WO-2009020580-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |