Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.44 |
| ▸ | MEN1 | O00255 | 8/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060719 | 0.84 | KMT2A (0.60) | KMT2AMEN1ATMALDH1A1HTT | |
| SCHEMBL27795750 | 0.84 | KMT2A (0.60) | KMT2AMEN1ATMALDH1A1HTT | |
| SCHEMBL8044111 | 0.84 | KMT2A (0.60) | KMT2AMEN1ATMALDH1A1HTT | |
| SCHEMBL12920945 | 0.81 | KMT2A (0.53) | KMT2AMEN1ATMPOLBALDH1A1 | |
| SCHEMBL13082765 | 0.79 | KMT2A (0.52) | KMT2AMEN1ATMALDH1A1LMNA | |
| SCHEMBL8062922 | 0.78 | KMT2A (0.41) | KMT2AMEN1ATMPOLBALDH1A1 | |
| SCHEMBL12920995 | 0.77 | KMT2A (0.49) | KMT2AMEN1ATMALDH1A1MAPT | |
| SCHEMBL4075272 | 0.73 | CNR2 (0.43) | ALDH1A1HTTSLC6A9 | |
| SCHEMBL5662464 | 0.73 | CNR2 (0.43) | ALDH1A1HTTSLC6A9 | |
| SCHEMBL12946361 | 0.72 | KMT2A (0.57) | KMT2AMEN1ATMALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020580-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |