Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 16/20 | 0.49 |
| ▸ | ESR1 | P03372 | 4/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190685 | 0.81 | CYP19A1 (0.62) | CYP19A1ESR1ESR2LMNAMAPK1 | |
| SCHEMBL28116449 | 0.78 | CYP19A1 (0.78) | CYP19A1ESR1ESR2LMNAMAPK1 | |
| SCHEMBL796194 | 0.78 | CYP19A1 (0.78) | CYP19A1ESR1ESR2LMNAMAPK1 | |
| SCHEMBL2846408 | 0.78 | CYP19A1 (0.78) | CYP19A1ESR1ESR2LMNAMAPK1 | |
| SCHEMBL6346280 | 0.78 | CYP19A1 (0.78) | CYP19A1ESR1ESR2LMNAMAPK1 | |
| SCHEMBL12544534 | 0.78 | CYP19A1 (0.78) | CYP19A1ESR1ESR2LMNAMAPK1 | |
| SCHEMBL2842300 | 0.78 | CYP19A1 (0.78) | CYP19A1ESR1ESR2LMNAMAPK1 | |
| SCHEMBL795609 | 0.78 | CYP19A1 (0.78) | CYP19A1ESR1ESR2LMNAMAPK1 | |
| SCHEMBL6346289 | 0.78 | CYP19A1 (0.78) | CYP19A1ESR1ESR2LMNAMAPK1 | |
| SCHEMBL795604 | 0.78 | CYP19A1 (0.78) | CYP19A1ESR1ESR2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037261-A2 | 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS ER-BETA AGONISTS | ENDECE, LLC (US) | 2012-03-22 | — | — | WO | disclosed |