Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16532097 | 0.85 | DGAT1 (0.42) | DGAT1SLC6A4KMT2AMAP2K1MAP2K2 | |
| SCHEMBL17907309 | 0.85 | DGAT1 (0.42) | DGAT1SLC6A4KMT2AMAP2K1MAP2K2 | |
| SCHEMBL28905087 | 0.83 | DGAT1 (0.52) | DGAT1SLC6A4KMT2ANPC1ALDH1A1 | |
| SCHEMBL6819503 | 0.82 | DGAT1 (0.47) | DGAT1SLC6A4KMT2ANPC1ALDH1A1 | |
| SCHEMBL6819500 | 0.82 | DGAT1 (0.47) | DGAT1SLC6A4KMT2ANPC1ALDH1A1 | |
| SCHEMBL27889504 | 0.78 | DGAT1 (0.59) | DGAT1SLC6A4KMT2ANPC1ALDH1A1 | |
| SCHEMBL22619988 | 0.78 | MEN1 (0.46) | SLC6A4KMT2AALDH1A1RAB9AMEN1 | |
| SCHEMBL13201524 | 0.77 | DGAT1 (0.50) | DGAT1SLC6A4KMT2ANPC1ALDH1A1 | |
| SCHEMBL11970700 | 0.76 | KDM1A (0.34) | DGAT1KDM1AKDM1BGPR27 | |
| SCHEMBL11970702 | 0.76 | KDM1A (0.34) | DGAT1KDM1AKDM1BGPR27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165440-A1 | JAK1 Inhibitors | EXELIXIS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165440-A1 | JAK1 Inhibitors | EXELIXIS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165440-A1 | JAK1 Inhibitors | JAK1, JAK2, JAK3 | DGAT1 3007/4885SLC6A4 4690/4885KMT2A 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.