Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21511511 | 0.82 | POLB (0.51) | POLBCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL21512890 | 0.82 | POLB (0.51) | POLBCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL5254341 | 0.81 | CYP3A4 (0.76) | POLBCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL4738964 | 0.78 | POLB (0.51) | POLBCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL8783042 | 0.78 | LMNA (0.57) | POLBCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL4541028 | 0.77 | MEN1 (0.52) | POLBCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL21511524 | 0.76 | LMNA (0.49) | POLBCYP3A4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21512891 | 0.76 | LMNA (0.49) | POLBCYP3A4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4738988 | 0.75 | SMN1; SMN2 (0.53) | POLBCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL4541025 | 0.75 | MEN1 (0.50) | POLBCYP3A4CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |