Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060971 | 1.00 | KCNQ2 (0.46) | KCNQ2TACR1MGLLNAAATSHR | |
| SCHEMBL8060970 | 1.00 | KCNQ2 (0.46) | KCNQ2TACR1MGLLNAAATSHR | |
| SCHEMBL1176583 | 0.89 | TACR1 (0.42) | KCNQ2TACR1MGLLNAAATSHR | |
| SCHEMBL5820901 | 0.89 | TACR1 (0.42) | KCNQ2TACR1MGLLNAAATSHR | |
| SCHEMBL1176585 | 0.89 | TACR1 (0.42) | KCNQ2TACR1MGLLNAAATSHR | |
| SCHEMBL1176581 | 0.89 | TACR1 (0.42) | KCNQ2TACR1MGLLNAAATSHR | |
| SCHEMBL2706185 | 0.89 | TACR1 (0.42) | KCNQ2TACR1MGLLNAAATSHR | |
| SCHEMBL13485472 | 0.87 | NAAA (0.42) | KCNQ2TACR1MGLLNAAATSHR | |
| SCHEMBL6181877 | 0.87 | TACR1 (0.44) | KCNQ2TACR1MGLLNAAATSHR | |
| SCHEMBL6181879 | 0.87 | TACR1 (0.44) | KCNQ2TACR1MGLLNAAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147090-A | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS USED TO TREAT DISEASES WHICH ARE EXACERBATED BY LOW LEVELS OF HDL CHOLESTEROL AND/OR HIGH LEVELS OF LDL-CHOLESTEROL AND TRIGLYCERIDES, SUCH AS ATHEROSCLEROSIS AND CARDIOVASCULAR | PFIZER INC. (US) | 2000-11-14 | — | — | US | claimed |