Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13647366 | 0.83 | RIPK1 (0.41) | RIPK1DPP4FAPDPP8DPP9 | |
| SCHEMBL3458357 | 0.80 | RIPK1 (0.42) | RIPK1DPP4FAPDPP8DPP9 | |
| SCHEMBL438764 | 0.80 | HTR2A (0.44) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL439586 | 0.80 | RIPK1 (0.39) | RIPK1DPP4FAPDPP8DPP9 | |
| SCHEMBL455119 | 0.80 | HTR2A (0.44) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL28026250 | 0.80 | RIPK1 (0.42) | RIPK1DPP4FAPDPP8DPP9 | |
| SCHEMBL10182854 | 0.78 | RIPK1 (0.39) | RIPK1DPP4FAPDPP8DPP9 | |
| SCHEMBL14718631 | 0.72 | RIPK1 (0.37) | RIPK1DPP4FAPDPP8DPP9 | |
| SCHEMBL13692314 | 0.72 | RIPK1 (0.37) | RIPK1DPP4FAPDPP8DPP9 | |
| SCHEMBL489929 | 0.72 | RIPK1 (0.41) | RIPK1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037155-A2 | TYROSINE KINASE INHIBITORS | GTX, INC. (US) | 2012-03-22 | — | — | WO | disclosed |