Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.82 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.82 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061608 | 1.00 | DHODH (0.82) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL8065734 | 0.90 | DHODH (1.00) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL8065731 | 0.90 | DHODH (1.00) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL21470188 | 0.88 | DHODH (0.75) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL8141637 | 0.88 | DHODH (0.84) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL21470195 | 0.88 | DHODH (0.84) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL8141640 | 0.88 | DHODH (0.84) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL8061707 | 0.88 | DHODH (0.84) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL8061709 | 0.88 | DHODH (0.84) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL8049318 | 0.86 | DHODH (0.82) | DHODHTRPM8TRPA1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |