Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651837 | 0.88 | APP (0.57) | APPSYKMEN1KMT2AMAPT | |
| SCHEMBL3656971 | 0.84 | SYK (0.55) | SYKMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL3653531 | 0.84 | APP (0.53) | APPSYKMAP3K5MEN1KMT2A | |
| SCHEMBL3655573 | 0.84 | SYK (0.54) | SYKMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL3653866 | 0.82 | APP (0.75) | APPSYKGCKMAP3K5MEN1 | |
| SCHEMBL3651460 | 0.82 | EPHX2 (0.56) | APPSYKNPC1EPHX2EGFR | |
| SCHEMBL3650073 | 0.79 | APP (0.52) | APPGCKMAP3K5MEN1KMT2A | |
| SCHEMBL3651458 | 0.78 | APP (0.48) | APPGCKMEN1KMT2AMAPK14 | |
| SCHEMBL3589836 | 0.74 | APP (0.76) | APPSYKMEN1KMT2AMAPT | |
| SCHEMBL2729349 | 0.73 | SYK (0.48) | SYKMEN1KMT2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044160-A1 | PYRIDINE DERIVATIVES FOR THE TREATMENT OF AMYLOID-RELATED DISEASES | SENEXIS LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |