Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25029917 | 0.85 | HTR2A (0.63) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL30886919 | 0.85 | HTR2A (0.63) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL4803628 | 0.85 | HTR2A (0.71) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL20647978 | 0.82 | HTR2A (0.56) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL1971767 | 0.82 | HTR2A (0.56) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL10646797 | 0.82 | HTR2A (0.67) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL6920054 | 0.79 | MTNR1A (0.70) | HTR2AMAPTSMN1; SMN2NPSR1MTNR1A | |
| SCHEMBL26663149 | 0.78 | HTR2A (0.61) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL6031028 | 0.78 | HTR2A (0.61) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL13217248 | 0.77 | HTR2A (0.50) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130005769-A1 | INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | STORCK PIERRE HENRI (GB) | 2013-01-03 | — | — | US | disclosed |
| US-20130005769-A1 | INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | STORCK PIERRE HENRI (GB) | 2013-01-03 | — | — | US | disclosed |
| US-8288377-B2 | Inhibitors of the interaction between MDM2 and p53 | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-10-16 | — | — | US | disclosed |
| US-8288377-B2 | Inhibitors of the interaction between MDM2 and p53 | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-10-16 | — | — | US | disclosed |
| EP-2203447-B1 | INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | JANSSEN PHARMACEUTICA NV (BE) | 2012-02-29 | — | — | EP | disclosed |
| US-20100216770-A1 | Inhibitors of the Interaction Between MDM2 and P53 | JANSSEN-CILAG (FR) | 2010-08-26 | — | — | US | disclosed |
| US-20100216770-A1 | Inhibitors of the Interaction Between MDM2 and P53 | JANSSEN-CILAG (FR) | 2010-08-26 | — | — | US | disclosed |
| WO-2009037343-A1 | INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | JANSSEN PHARMACEUTICA NV (BE) | 2009-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216770-A1 | Inhibitors of the Interaction Between MDM2 and P53 | TP53, MDM2, TP53BP1 | HTR2A 2847/4885MAPT 1584/4885SMN1; SMN2 4155/4885 |
| US-20130005769-A1 | INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | TP53, MDM2, TP53BP1 | HTR2A 2847/4885MAPT 1584/4885SMN1; SMN2 4155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.