Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 6/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8056417 | 0.86 | CFTR (0.39) | CFTRNOTUMMAPTKCNN4SOS1 | |
| SCHEMBL8056235 | 0.84 | CFTR (0.38) | CFTRNOTUMMAPTKCNN4SOS1 | |
| SCHEMBL8056232 | 0.84 | CFTR (0.38) | CFTRNOTUMMAPTKCNN4SOS1 | |
| SCHEMBL8058223 | 0.83 | CFTR (0.37) | CFTRNOTUMMAPTKCNN4SOS1 | |
| SCHEMBL8058221 | 0.83 | CFTR (0.37) | CFTRNOTUMMAPTKCNN4SOS1 | |
| SCHEMBL8058193 | 0.82 | VEGFA (0.41) | VEGFAMAPTKCNN4PDK2 | |
| SCHEMBL8057061 | 0.81 | KDM4E (0.36) | VEGFAMAPT | |
| SCHEMBL8045172 | 0.78 | VEGFA (0.35) | VEGFAMAPT | |
| SCHEMBL8056401 | 0.77 | — | — | |
| SCHEMBL8062790 | 0.75 | NOTUM (0.43) | CFTRNOTUMMAPTSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |