Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 6/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058223 | 1.00 | CFTR (0.37) | CFTRNOTUMSOS1PDK2MAPT | |
| SCHEMBL8056232 | 0.89 | CFTR (0.38) | CFTRNOTUMSOS1PDK2MAPT | |
| SCHEMBL8056235 | 0.89 | CFTR (0.38) | CFTRNOTUMSOS1PDK2MAPT | |
| SCHEMBL8062747 | 0.84 | SLC9A1 (0.38) | — | |
| SCHEMBL8062750 | 0.84 | SLC9A1 (0.38) | — | |
| SCHEMBL8058006 | 0.84 | CTSL (0.35) | SOS1PDK2MAPT | |
| SCHEMBL8058007 | 0.84 | CTSL (0.35) | SOS1PDK2MAPT | |
| SCHEMBL8056918 | 0.83 | ALDH1A1 (0.33) | MAPT | |
| SCHEMBL8056913 | 0.83 | ALDH1A1 (0.33) | MAPT | |
| SCHEMBL8062894 | 0.83 | CFTR (0.40) | CFTRNOTUMSOS1PDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |