Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343630 | 0.79 | CA12 (0.65) | MAPTMTNR1AMTNR1BCA12CA1 | |
| SCHEMBL24425881 | 0.79 | ALDH1A1 (0.53) | MAPTMTNR1AMTNR1BCA12CA1 | |
| SCHEMBL7928344 | 0.79 | MAPT (0.50) | MAPTMTNR1AMTNR1BCA12CA1 | |
| SCHEMBL17024115 | 0.79 | SMN1; SMN2 (0.51) | APPSMN1; SMN2MAOBAOC3NPC1 | |
| SCHEMBL645945 | 0.78 | KCNA3 (0.58) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL8434882 | 0.77 | CA12 (0.61) | MAPTMTNR1AMTNR1BCA12CA1 | |
| SCHEMBL9808262 | 0.77 | MAPT (0.62) | MAPTMTNR1AMTNR1BCA12CA1 | |
| SCHEMBL77535 | 0.76 | ALDH1A1 (0.60) | MAPTMTNR1AMTNR1BCA12CA1 | |
| SCHEMBL14984020 | 0.75 | MAPT (0.60) | MAPTMTNR1AMTNR1BCA12CA1 | |
| SCHEMBL30514009 | 0.75 | MAPT (0.60) | MAPTMTNR1AMTNR1BCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730861-B1 | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | SIGMA TAU IND FARMACEUTI (IT) | 2000-08-02 | — | — | EP | disclosed |
| US-5591777-A | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1997-01-07 | — | — | US | disclosed |
| EP-0730861-A1 | Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1996-09-11 | — | — | EP | disclosed |