Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 5/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031553 | 1.00 | ITGB2 (0.41) | ITGB2ICAM1ITGALPGRNR3C1 | |
| SCHEMBL3031304 | 0.91 | PGR (0.43) | ITGB2ICAM1ITGALPGREGLN1 | |
| SCHEMBL2784445 | 0.90 | ITGB2 (0.41) | ITGB2ICAM1ITGALPGRNR3C1 | |
| SCHEMBL3046626 | 0.88 | SUCNR1 (0.37) | ITGB2ICAM1ITGALARSUCNR1 | |
| SCHEMBL3040619 | 0.85 | PGR (0.37) | ITGB2ICAM1ITGALPGRNR3C1 | |
| SCHEMBL3028215 | 0.85 | PGR (0.39) | ITGB2ICAM1ITGALPGRNR3C1 | |
| SCHEMBL3034924 | 0.84 | ITGB2 (0.43) | ITGB2ICAM1ITGALPGRNR3C1 | |
| SCHEMBL2784155 | 0.84 | PIK3CA (0.36) | ITGB2ICAM1ITGALPGRNR3C1 | |
| SCHEMBL2785547 | 0.84 | SLC11A2 (0.44) | GRIN1GRIN2BCD274 | |
| SCHEMBL3037812 | 0.82 | ITGB2 (0.37) | ITGB2ICAM1ITGALPGRNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209373-B1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2009045386-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | disclosed |