SCHEMBL8063276

SCHEMBL8063276

C=CCCCc1ccc(F)cc1

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.44
MAOB P27338 2/20 0.41
CYP19A1 P11511 1/20 0.40
AOC3 Q16853 2/20 0.39
IDO1 P14902 1/20 0.39
LOXL2 Q9Y4K0 1/20 0.39
AOC2 O75106 1/20 0.39
MAOA P21397 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14027699 0.94 MAOB (0.50) TAAR1SMN1; SMN2MAOBCYP19A1AOC3
SCHEMBL7365318 0.94 TAAR1 (0.45) TAAR1SMN1; SMN2MAOBCYP19A1AOC3
SCHEMBL8073020 0.92 USP2 (0.44) TAAR1SMN1; SMN2MAOBCYP19A1HDAC4
SCHEMBL8072476 0.92 USP2 (0.44) TAAR1SMN1; SMN2MAOBCYP19A1HDAC4
SCHEMBL8077499 0.92 USP2 (0.44) TAAR1SMN1; SMN2MAOBCYP19A1HDAC4
SCHEMBL8072561 0.92 USP2 (0.44) TAAR1SMN1; SMN2MAOBCYP19A1HDAC4
SCHEMBL29819537 0.89 HDAC1 (0.43) MAOBL3MBTL1HDAC4HDAC1
SCHEMBL14027703 0.88 MAOB (0.48) TAAR1SMN1; SMN2MAOBCYP19A1HDAC4
SCHEMBL7563217 0.86 TAAR1 (0.50) TAAR1SMN1; SMN2MAOBAOC3IDO1
SCHEMBL7791382 0.86 GRIN2D (0.41) TAAR1SMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118084726-A 1-Cyano-2-hydroxy-5-fluoro compound and preparation method thereof 南京工业大学 2024-05-28 CN claimed
CN-116283474-B Method for catalyzing olefin migration by palladium 常州大学 2025-05-27 CN disclosed
CN-118084726-A 1-Cyano-2-hydroxy-5-fluoro compound and preparation method thereof 南京工业大学 2024-05-28 CN disclosed
CN-116283474-A Method for catalyzing olefin migration by palladium 常州大学 2023-06-23 CN disclosed
US-6063940-A Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-05-16 US disclosed
US-5637736-A Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-06-10 US disclosed
EP-0492474-B1 1,3-Dioxolane derivatives as cholesterol-lowering agents SYNTEX INC (US) 1997-03-05 EP disclosed
EP-0637580-A1 Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-02-08 EP disclosed
US-5158949-A 1,3-DIOXOLANE DERIVATIVES AS CHOLESTEROL-LOWERING AGENTS SYNTEX (U.S.A.) INC. (US) 1992-10-27 US disclosed
EP-0492474-A1 1,3-Dioxolane derivatives as cholesterol-lowering agents SYNTEX (U.S.A.) INC. (US) 1992-07-01 EP disclosed