Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 6/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066751 | 0.84 | HTR2A (0.55) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL8048114 | 0.82 | HTR2A (0.59) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL12811112 | 0.81 | HTR2A (0.51) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL8065759 | 0.81 | HTR2A (0.51) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL8043018 | 0.80 | MAPT (0.64) | HTR2AMAPTSMN1; SMN2NPSR1CDK2 | |
| SCHEMBL18784114 | 0.78 | HTR2A (0.56) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL8044595 | 0.76 | HTR2A (0.53) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL18783078 | 0.75 | HTR2A (0.56) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL16420390 | 0.74 | HTR2A (0.47) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 | |
| SCHEMBL8042979 | 0.73 | MAPT (0.53) | HTR2AMAPTSMN1; SMN2NPSR1SOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009019274-A1 | SUBSTITUTED PHENYLENEDIAMINES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-12 | — | — | WO | disclosed |