Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048114 | 0.88 | HTR2A (0.59) | HTR2AMAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL12811112 | 0.86 | HTR2A (0.51) | HTR2AMAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8065759 | 0.86 | HTR2A (0.51) | HTR2AMAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15267556 | 0.85 | ALDH1A1 (0.47) | HTR2AMAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8063649 | 0.84 | HTR2A (0.49) | HTR2AMAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15267545 | 0.83 | ALDH1A1 (0.45) | HTR2AMAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8265777 | 0.83 | ALDH1A1 (0.69) | HTR2AMAPTNPSR1ALDH1A1NPC1 | |
| SCHEMBL18784114 | 0.83 | HTR2A (0.56) | HTR2AMAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8043018 | 0.83 | MAPT (0.64) | HTR2AMAPTNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8044595 | 0.81 | HTR2A (0.53) | HTR2AMAPTNPSR1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853406-B2 | Substituted phenylenediamines as inhibitors of the interaction between MDM2 and P53 | JANSSEN PHARMACEUTICA NV (BE) | 2014-10-07 | — | — | US | disclosed |
| WO-2009019274-A1 | SUBSTITUTED PHENYLENEDIAMINES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-12 | — | — | WO | disclosed |