Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 10/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26326335 | 1.00 | VDR (0.48) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL3179666 | 1.00 | VDR (0.48) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL12398151 | 0.95 | VDR (0.45) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL8527105 | 0.91 | VDR (0.46) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL14569115 | 0.91 | VDR (0.51) | VDRHDAC6 | |
| SCHEMBL3178247 | 0.90 | VDR (0.54) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL25410119 | 0.89 | VDR (0.53) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL25894696 | 0.89 | VDR (0.53) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL25894630 | 0.89 | VDR (0.53) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL25410122 | 0.89 | VDR (0.53) | VDRHDAC3HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734376-B1 | VITAMIN D AMINE AND AMIDE DERIVATIVES | RES INST FOR (US) | 2000-09-20 | — | — | EP | disclosed |
| US-6013814-A | Vitamin D analogues | RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY, INC. (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0751932-B1 | VITAMIN-D AMIDE DERIVATIVES | RES INST MEDICINE CHEM (US) | 1999-06-09 | — | — | EP | disclosed |
| US-5872140-A | Vitamin D analogues | RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY, INC. (US) | 1999-02-16 | — | — | US | disclosed |
| EP-0710227-B1 | VITAMIN D ANALOGUES | RES INST MEDICINE CHEM (US) | 1998-10-21 | — | — | EP | disclosed |
| US-5811562-A | Vitamin-D amide derivatives | RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY INC. (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0696275-B1 | VITAMIN D AMIDE DERIVATIVES | RES INST MEDICINE CHEM (US) | 1998-08-12 | — | — | EP | disclosed |
| US-5786347-A | Vitamin D amine and amide derivatives | RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY, INC. (US) | 1998-07-28 | — | — | US | disclosed |
| US-5756733-A | Vitamin D amide derivatives | RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0751932-A1 | VITAMIN-D AMIDE DERIVATIVES | HOLMES, Michael John (GB) | 1997-01-08 | — | — | EP | disclosed |
| EP-0734376-A1 | VITAMIN D AMINE AND AMIDE DERIVATIVES | RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY INC. (US) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995025718-A1 | VITAMIN-D AMIDE DERIVATIVES | HOLMES, MICHAEL, JOHN (GB) | 1995-09-28 | — | — | WO | disclosed |
| WO-1995016672-A1 | VITAMIN D AMINE AND AMIDE DERIVATIVES | HOLMES, MICHAEL, JOHN (GB) | 1995-06-22 | — | — | WO | disclosed |