Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.63 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.63 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063998 | 1.00 | TRPA1 (0.63) | TRPA1TRPM8EGFRTRPM2LTB4R | |
| SCHEMBL2780616 | 0.88 | TRPA1 (0.71) | TRPA1TRPM8EGFRTRPM2LTB4R | |
| SCHEMBL2780618 | 0.88 | TRPA1 (0.71) | TRPA1TRPM8EGFRTRPM2LTB4R | |
| SCHEMBL8060365 | 0.81 | TRPA1 (0.58) | TRPA1TRPM8EGFRTRPM2MEN1 | |
| SCHEMBL8144449 | 0.81 | GRIK1 (0.62) | TRPA1TRPM8EGFRMEN1KMT2A | |
| SCHEMBL8144447 | 0.81 | GRIK1 (0.62) | TRPA1TRPM8EGFRMEN1KMT2A | |
| SCHEMBL8060362 | 0.81 | TRPA1 (0.58) | TRPA1TRPM8EGFRTRPM2MEN1 | |
| SCHEMBL2779338 | 0.78 | TRPA1 (1.00) | TRPA1TRPM8EGFRTRPM2LTB4R | |
| SCHEMBL2779340 | 0.78 | TRPA1 (1.00) | TRPA1TRPM8EGFRTRPM2LTB4R | |
| SCHEMBL8635715 | 0.77 | TRPA1 (0.78) | TRPA1TRPM8TRPM2LTB4RNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |