Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | PGK2 | P07205 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063959 | 0.82 | SRC (0.47) | POLBCYP2D6LMNAMAPK1SRC | |
| SCHEMBL5053006 | 0.81 | KDM4E (0.41) | CYP2D6SRCKDM4EALDH1A1 | |
| SCHEMBL5053063 | 0.79 | SRC (0.44) | CYP2D6LMNAMAPK1SRCKDM4E | |
| SCHEMBL5053168 | 0.78 | ACP3 (0.41) | POLB | |
| SCHEMBL5051144 | 0.78 | ALOX15 (0.39) | POLBCYP2D6LMNAMAPK1SRC | |
| SCHEMBL5057894 | 0.77 | SRC (0.42) | CYP2D6LMNAMAPK1SRCKDM4E | |
| SCHEMBL5054278 | 0.75 | ACP3 (0.41) | POLB | |
| SCHEMBL5057994 | 0.75 | GGH (0.43) | POLBCYP2D6ALDH1A1 | |
| SCHEMBL5052757 | 0.75 | PPARA (0.43) | POLBCYP2D6LMNASRCALDH1A1 | |
| SCHEMBL2856838 | 0.74 | POLB (0.53) | POLBCYP2D6MAPK1SRCPGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |