Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921330 | 0.82 | TAAR1 (0.57) | TAAR1LMNASMN1; SMN2HPGDNPC1 | |
| SCHEMBL20146704 | 0.82 | TAAR1 (0.73) | TAAR1SMN1; SMN2NPC1RAB9APTGS1 | |
| SCHEMBL27340256 | 0.81 | TAAR1 (0.62) | TRPM8TAAR1SMN1; SMN2NPC1PTGS1 | |
| SCHEMBL27115453 | 0.81 | TAAR1 (0.55) | TAAR1LMNASMN1; SMN2HPGDNPC1 | |
| SCHEMBL27114662 | 0.81 | TAAR1 (0.55) | TAAR1LMNASMN1; SMN2HPGDNPC1 | |
| SCHEMBL9936845 | 0.81 | TAAR1 (0.55) | TAAR1LMNASMN1; SMN2HPGDNPC1 | |
| SCHEMBL9808857 | 0.81 | TAAR1 (0.55) | TAAR1LMNASMN1; SMN2HPGDNPC1 | |
| SCHEMBL6734915 | 0.80 | TAAR1 (0.70) | TAAR1SMN1; SMN2NPC1RAB9APTGS1 | |
| SCHEMBL8571535 | 0.80 | TAAR1 (0.70) | TAAR1SMN1; SMN2NPC1RAB9APTGS1 | |
| SCHEMBL7116263 | 0.80 | TAAR1 (0.70) | TAAR1SMN1; SMN2NPC1RAB9APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733627-B1 | Thiophene compounds, a method for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-06-28 | — | — | EP | disclosed |
| US-5670535-A | COMPOUNDS FOR TREATMENT OF BONE LOSS IN ANIMALS | ADIR ET COMPAGNIE (FR) | 1997-09-23 | — | — | US | disclosed |
| EP-0733627-A1 | Thiophene compounds, a method for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-09-25 | — | — | EP | disclosed |