Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13663655 | 0.89 | PDE4B (0.42) | PDE4BNPC1HPGDRAB9AGPR119 | |
| SCHEMBL8064836 | 0.89 | SRC (0.41) | PDE4BSRCNR1H2 | |
| SCHEMBL3945721 | 0.88 | PDE4B (0.42) | PDE4BNPC1HPGDRAB9AGPR119 | |
| SCHEMBL13663724 | 0.83 | PDE4B (0.39) | PDE4BNPC1HPGDRAB9AGPR119 | |
| SCHEMBL4297046 | 0.83 | ABCB1 (0.39) | PDE4BNPC1HPGDRAB9AGPR119 | |
| SCHEMBL13765329 | 0.82 | MEN1 (0.36) | NR1H2 | |
| SCHEMBL8064390 | 0.78 | HDAC8 (0.42) | — | |
| SCHEMBL25694140 | 0.78 | CHRNB2 (0.47) | NPC1SRC | |
| SCHEMBL8059551 | 0.78 | CYP1A2 (0.45) | PDE4BSRCNR1H2 | |
| SCHEMBL16080305 | 0.77 | NR1H2 (0.51) | SRCNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |