Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8069731 | 0.90 | PDE4D (0.75) | PDE4DPDE4BALDH1A1FBP1MEN1 | |
| Hydrochloric Acid SCHEMBL3793941 | 0.89 | PDE4D (0.73) | PDE4DPDE4BALDH1A1FBP1MEN1 | |
| SCHEMBL4326773 | 0.87 | PDE4D (0.71) | PDE4DPDE4BFBP1PTGES2HTR7 | |
| SCHEMBL4320297 | 0.86 | PDE4D (0.84) | PDE4DPDE4BALDH1A1FBP1MEN1 | |
| SCHEMBL3466522 | 0.86 | PDE4D (1.00) | PDE4DPDE4BALDH1A1FBP1MEN1 | |
| SCHEMBL3790675 | 0.84 | PDE4D (0.70) | PDE4DPDE4BALDH1A1PTGES2HPGD | |
| SCHEMBL17633592 | 0.84 | PDE4D (0.66) | PDE4DPDE4BHTR7POLBHPGD | |
| SCHEMBL3788487 | 0.84 | PDE4D (0.69) | PDE4DPDE4BALDH1A1GAAPTGES2 | |
| SCHEMBL8069704 | 0.84 | PDE4D (0.54) | PDE4DPDE4BALDH1A1MEN1GAA | |
| Hydrochloric Acid SCHEMBL3793938 | 0.84 | PDE4D (0.69) | PDE4DPDE4BGAAPTGES2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |