Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | AGPAT2 | O15120 | 10/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.42 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | TLK1 | Q9UKI8 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15906098 | 0.88 | AGPAT2 (0.55) | PDE4DPDE4BAGPAT2MEN1ALDH1A1 | |
| SCHEMBL4330980 | 0.87 | PDE4D (0.54) | PDE4DPDE4BAGPAT2ALDH1A1MAPT | |
| SCHEMBL13578457 | 0.84 | PDE4D (0.52) | PDE4DPDE4BAGPAT2MEN1ALDH1A1 | |
| SCHEMBL8072297 | 0.84 | PDE4D (0.76) | PDE4DPDE4BAGPAT2MEN1ALDH1A1 | |
| SCHEMBL8064607 | 0.84 | PDE4D (0.76) | PDE4DPDE4BMEN1ALDH1A1GAA | |
| SCHEMBL8024587 | 0.83 | PDE4D (0.55) | PDE4DPDE4BMEN1ALDH1A1GAA | |
| SCHEMBL8070016 | 0.83 | PDE4D (0.50) | PDE4DPDE4BAGPAT2MEN1ALDH1A1 | |
| SCHEMBL3788953 | 0.82 | MEN1 (0.50) | PDE4DPDE4BAGPAT2MEN1ALDH1A1 | |
| SCHEMBL5099550 | 0.81 | PDE4D (0.56) | PDE4DPDE4BAGPAT2ALDH1A1MAPT | |
| SCHEMBL8066343 | 0.81 | ALDH1A1 (0.48) | PDE4DMEN1ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |