Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15996997 | 0.84 | PDGFRB (0.51) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL28819003 | 0.83 | COMT (0.46) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL12000739 | 0.83 | TDP1 (0.49) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL6626231 | 0.81 | ALDH1A1 (0.46) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL8744077 | 0.81 | ALDH1A1 (0.39) | TDP1COMTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL1478701 | 0.80 | ALDH1A1 (0.60) | TDP1TSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL3291904 | 0.80 | ALDH1A1 (0.60) | TDP1TSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL10558853 | 0.80 | TSHR (0.47) | TDP1TSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL2901232 | 0.80 | TDP1 (0.47) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL11217561 | 0.80 | SMN1; SMN2 (0.47) | PDGFRBFGFR1PDGFRAFLT1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751768-B1 | ANTI-VIRAL AND ANTI-CANCER AGENT | RADOPATH PHARMACEUTICALS INTER (GB) | 2000-12-27 | — | — | EP | disclosed |
| EP-1016405-A2 | Arylating medicaments | Radopath Pharmaceuticals International Limited (GB) | 2000-07-05 | — | — | EP | disclosed |
| EP-0751768-A1 | ANTI-VIRAL AND ANTI-CANCER AGENTS | RADOPATH LIMITED (GB) | 1997-01-08 | — | — | EP | disclosed |
| EP-0700287-A1 | ARYLATING MEDICAMENTS | RADOPATH LIMITED (GB) | 1996-03-13 | — | — | EP | disclosed |
| EP-0677292-A1 | Anti-viral and anti-cancer agents | RADOPATH LIMITED (GB) | 1995-10-18 | — | — | EP | disclosed |
| WO-1995024897-A1 | ANTI-VIRAL AND ANTI-CANCER AGENTS | RADOPATH LIMITED (GB) | 1995-09-21 | — | — | WO | disclosed |
| WO-1994027584-A2 | ARYLATING MEDICAMENTS | RADOPATH LIMITED (GB) | 1994-12-08 | — | — | WO | disclosed |