Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Naphthoquinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 6/20 | 0.70 |
| ▸ | IDO1 | P14902 | 4/20 | 0.70 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.70 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.70 |
| ▸ | MAOA | P21397 | 2/20 | 0.70 |
| ▸ | MAOB | P27338 | 2/20 | 0.70 |
| ▸ | SNCA | P37840 | 2/20 | 0.70 |
| ▸ | AKT1 | P31749 | 1/20 | 0.70 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.70 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.70 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.70 |
| ▸ | TOP1 | P11387 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RECQL | P46063 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthoquinone SCHEMBL27583560 | 0.91 | CDC25B (0.58) | CDC25BIDO1PIN1EHMT2MAOA | |
| Naphthoquinone SCHEMBL4116599 | 0.91 | CDC25B (0.64) | CDC25BIDO1PIN1EHMT2MAOA | |
| Naphthoquinone SCHEMBL27995889 | 0.87 | CDC25B (0.82) | CDC25BIDO1PIN1EHMT2MAOA | |
| Naphthoquinone SCHEMBL28000500 | 0.84 | IDO1 (0.61) | CDC25BIDO1PIN1EHMT2MAOA | |
| Naphthoquinone SCHEMBL4110937 | 0.84 | CDC25B (0.61) | CDC25BIDO1PIN1EHMT2MAOA | |
| Naphthoquinone SCHEMBL27749420 | 0.84 | CDC25B (0.61) | CDC25BIDO1PIN1EHMT2MAOA | |
| Naphthoquinone SCHEMBL8861335 | 0.84 | IDO1 (1.00) | CDC25BIDO1PIN1EHMT2MAOA | |
| Naphthoquinone SCHEMBL29354680 | 0.84 | IDO1 (1.00) | CDC25BIDO1PIN1EHMT2MAOA | |
| Naphthoquinone SCHEMBL11359780 | 0.84 | IDO1 (1.00) | CDC25BIDO1PIN1EHMT2MAOA | |
| Naphthoquinone SCHEMBL42139 | 0.84 | IDO1 (1.00) | CDC25BIDO1PIN1EHMT2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114642637-B | Pure naphthoquinone compound nano particle and preparation method of carrier-free surfactant-free nano particle | 吉林大学 | 2022-12-30 | — | — | CN | disclosed |
| CN-114642637-A | Pure naphthoquinone compound nano particle and preparation method of carrier-free surfactant-free nano particle | 吉林大学 | 2022-06-21 | — | — | CN | disclosed |
| EP-1009373-A1 | ANTIBACTERIAL DEODORIZING COMPOSITIONS | Innoscent Ltd. (IL) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011234-A1 | ANTIBACTERIAL DEODORIZING COMPOSITIONS | INNOSCENT LTD. (IL) | 1999-03-11 | — | — | WO | disclosed |