Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL329140 | 0.76 | RECQL (0.47) | RECQLCYP1A2KMOSLC22A12CYP11B1 | |
| SCHEMBL276288 | 0.73 | RECQL (0.48) | RECQLCYP1A2KMOSLC22A12CYP11B1 | |
| SCHEMBL30270004 | 0.73 | KDM4E (0.56) | RECQLCYP1A2KMOCYP11B1CYP11B2 | |
| SCHEMBL13052911 | 0.73 | CYP11B2 (0.55) | RECQLCYP1A2KMOCYP11B1CYP11B2 | |
| SCHEMBL729956 | 0.73 | KDM4E (0.56) | RECQLCYP1A2KMOCYP11B1CYP11B2 | |
| SCHEMBL315321 | 0.71 | RECQL (0.47) | RECQLCYP1A2KMOSLC22A12CYP11B1 | |
| SCHEMBL787026 | 0.71 | RECQL (0.47) | RECQLCYP1A2KMOSLC22A12CYP11B1 | |
| SCHEMBL13647386 | 0.71 | RECQL (0.47) | RECQLCYP1A2KMOSLC22A12CYP11B1 | |
| SCHEMBL61456 | 0.71 | RECQL (0.47) | RECQLCYP1A2KMOSLC22A12CYP11B1 | |
| SCHEMBL2010731 | 0.71 | RECQL (0.47) | RECQLCYP1A2KMOSLC22A12CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037411-A9 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012037411-A2 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |