SCHEMBL8064782

SCHEMBL8064782

O=C(OCC(O)C(O)COC(=O)c1ccccc1)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 1.00
PRKCA P17252 1/20 0.64
ADRB2 P07550 2/20 0.60
ADRB1 P08588 2/20 0.60
ADRB3 P13945 2/20 0.60
TDP1 Q9NUW8 2/20 0.59
MAPK1 P28482 1/20 0.57
HIF1A Q16665 1/20 0.57
SLC6A2 P23975 1/20 0.57
SLC6A3 Q01959 1/20 0.57
KMT2A Q03164 1/20 0.57
LMNA P02545 2/20 0.55
SLC1A5 Q15758 1/20 0.53
F2 P00734 1/20 0.52
TSHR P16473 3/20 0.52
KDM4E B2RXH2 1/20 0.49
GAA P10253 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
TP53 P04637 1/20 0.48
NPC1 O15118 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1862116 1.00 ALDH1A1 (1.00) ALDH1A1PRKCAADRB2ADRB1ADRB3
SCHEMBL1030284 1.00 ALDH1A1 (1.00) ALDH1A1PRKCAADRB2ADRB1ADRB3
SCHEMBL13625428 1.00 ALDH1A1 (1.00) ALDH1A1PRKCAADRB2ADRB1ADRB3
SCHEMBL1868286 1.00 ALDH1A1 (1.00) ALDH1A1PRKCAADRB2ADRB1ADRB3
SCHEMBL23227764 0.92 ALDH1A1 (0.85) ALDH1A1PRKCAADRB2ADRB1ADRB3
SCHEMBL1030023 0.92 ALDH1A1 (0.85) ALDH1A1PRKCAADRB2ADRB1ADRB3
SCHEMBL1027311 0.92 ALDH1A1 (0.85) ALDH1A1PRKCAADRB2ADRB1ADRB3
SCHEMBL28825260 0.89 ALDH1A1 (0.79) ALDH1A1PRKCAADRB2ADRB1ADRB3
SCHEMBL28342950 0.89 ALDH1A1 (0.79) ALDH1A1PRKCAADRB2ADRB1ADRB3
SCHEMBL295042 0.88 ALDH1A1 (0.78) ALDH1A1PRKCAADRB2ADRB1ADRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016130417-A1 OMEGA-3 FATTY ACID PRODRUG COMPOUNDS AND USES THEREOF OMTHERA PHARMACEUTICALS INC (US) 2016-08-18 WO disclosed
WO-2009030733-A1 METHOD FOR THE SYNTHESIS OF 4-ALKOXY-, 4-HYDROXY- AND 4-ARYLOXY-SUBSTITUTED TETRAHYDRO-FURO[3,4-B]FURAN-2(3H)-ONE COMPOUNDS DSM IP ASSETS B.V. (NL) 2009-03-12 WO disclosed