Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | METAP1 | P53582 | 4/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033688 | 0.83 | CYP19A1 (0.77) | CYP19A1HDAC1METAP1SIGMAR1ACHE | |
| SCHEMBL3314894 | 0.75 | CYP19A1 (1.00) | CYP19A1HDAC1METAP1SIGMAR1 | |
| SCHEMBL27649365 | 0.75 | CYP19A1 (0.56) | CYP19A1HDAC1METAP1SIGMAR1ACHE | |
| SCHEMBL27530046 | 0.73 | CYP19A1 (0.54) | CYP19A1HDAC1METAP1SIGMAR1ACHE | |
| SCHEMBL12269444 | 0.72 | ACHE (0.67) | CYP19A1HDAC1METAP1SIGMAR1ACHE | |
| SCHEMBL28883696 | 0.72 | CYP19A1 (0.53) | CYP19A1HDAC1METAP1ACHE | |
| SCHEMBL19748689 | 0.71 | CYP19A1 (0.63) | CYP19A1HDAC1METAP1SIGMAR1ACHE | |
| Bromide SCHEMBL2334441 | 0.71 | ACHE (0.68) | CYP19A1HDAC1METAP1SIGMAR1ACHE | |
| Hydrochloric Acid SCHEMBL2332692 | 0.71 | ACHE (0.66) | CYP19A1HDAC1METAP1SIGMAR1ACHE | |
| SCHEMBL866816 | 0.70 | METAP1 (0.67) | CYP19A1METAP1SIGMAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820426-B1 | SUBSTITUTED DIBENZ[a,f]AZULENES AND METHODS OF PREPARATION | ORTHO PHARMA CORP (US) | 2000-06-14 | — | — | EP | disclosed |
| US-5834521-A | TREATMENT OF PROGESTIN MEDIATED MALADIES; OSTEOPOROSIS, CANCER | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-11-10 | — | — | US | disclosed |
| EP-0820426-A1 | SUBSTITUTED DIBENZ[a,f]AZULENES AND METHODS OF PREPARATION | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996028403-A1 | SUBSTITUTED DIBENZ[a,f]AZULENES AND METHODS OF PREPARATION | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-09-19 | — | — | WO | disclosed |