Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 5/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29894167 | 1.00 | GPR3 (0.48) | GPR3TRPV1MAPTMAPK1RECQL | |
| SCHEMBL8072923 | 0.87 | TRPV1 (0.46) | GPR3TRPV1MAPTMAPK1RECQL | |
| SCHEMBL8074952 | 0.84 | HSP90AA1 (0.42) | TRPV1MAPTMAPK1RECQLL3MBTL1 | |
| Potassium Ion SCHEMBL11423611 | 0.84 | GPR3 (0.43) | GPR3TRPV1MAPTMAPK1RECQL | |
| SCHEMBL8461833 | 0.83 | GPR3 (0.46) | GPR3FFAR4FFAR1KIF11AKR1C2 | |
| SCHEMBL10825618 | 0.83 | MRGPRX4 (0.48) | GPR3FFAR4FFAR1CYP2C9SCN5A | |
| SCHEMBL10598726 | 0.83 | HSP90AA1 (0.41) | TRPV1MAPTMAPK1RECQLL3MBTL1 | |
| SCHEMBL11065683 | 0.83 | FFAR4 (0.48) | GPR3TRPV1MAPTMAPK1RECQL | |
| SCHEMBL543035 | 0.81 | GPR3 (0.44) | GPR3MAPK1FFAR4FFAR1CYP2C9 | |
| SCHEMBL1275598 | 0.81 | GPR3 (0.44) | GPR3TRPV1MAPTMAPK1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820981-B1 | Process for the preparation of 2-trifluoromethoxy-aniline | BAYER AG (DE) | 2000-10-18 | — | — | EP | claimed |
| EP-0863869-B1 | METHOD OF PREPARING 2-TRIFLUOROMETHOXYBENZENE SULPHONAMIDE | BAYER AG (DE) | 2000-08-16 | — | — | EP | claimed |
| US-5840983-A | Process for preparing 2-trifluoromethoxy-aniline | BAYER AKTIENGESELLSCHAFT (DE) | 1998-11-24 | — | — | US | claimed |
| EP-0820981-A1 | Process for the preparation of 2-trifluoromethoxy-aniline | BAYER AG (DE) | 1998-01-28 | — | — | EP | claimed |
| JP-10095755-A | — | — | None | — | — | JP | disclosed |
| CN-112159329-B | Co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene | 大连奇凯医药科技有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-112159329-A | Co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene | 大连奇凯医药科技有限公司 | 2021-01-01 | — | — | CN | disclosed |
| EP-0820981-B1 | Process for the preparation of 2-trifluoromethoxy-aniline | BAYER AG (DE) | 2000-10-18 | — | — | EP | disclosed |
| EP-0863869-B1 | METHOD OF PREPARING 2-TRIFLUOROMETHOXYBENZENE SULPHONAMIDE | BAYER AG (DE) | 2000-08-16 | — | — | EP | disclosed |
| US-5925788-A | Method of preparing 2-trifluoromethoxy-benzenesulphonamide | BAYER AKTIENGESELLSCHAFT (DE) | 1999-07-20 | — | — | US | disclosed |
| US-5840983-A | Process for preparing 2-trifluoromethoxy-aniline | BAYER AKTIENGESELLSCHAFT (DE) | 1998-11-24 | — | — | US | disclosed |
| JP-H1095755-A | PRODUCTION OF 2-TRIFLUOROMETHOXY-ANILINE | BAYER AG | 1998-04-14 | — | — | JP | disclosed |
| EP-0820981-A1 | Process for the preparation of 2-trifluoromethoxy-aniline | BAYER AG (DE) | 1998-01-28 | — | — | EP | disclosed |
| EP-0820981-A1 | Process for the preparation of 2-trifluoromethoxy-aniline | BAYER AG (DE) | 1998-01-28 | — | — | EP | disclosed |