Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | GOT1 | P17174 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9925249 | 0.94 | HSP90AA1 (0.41) | HSP90AA1GAAGOT1KDM4ELMNA | |
| SCHEMBL13983476 | 0.89 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 | |
| SCHEMBL13983147 | 0.88 | HSP90AA1 (0.43) | HSP90AA1GAAKDM4ELMNAHSP90AB1 | |
| SCHEMBL13983105 | 0.85 | HSP90AA1 (0.45) | HSP90AA1GAAKDM4ELMNAPAX8 | |
| SCHEMBL14933295 | 0.83 | BRD4 (0.38) | HSP90AA1GAAGOT1HPGDSDHFR | |
| SCHEMBL806551 | 0.83 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1 | |
| SCHEMBL12180265 | 0.82 | HSP90AA1 (0.44) | HSP90AA1GAAKDM4ELMNAHSP90AB1 | |
| SCHEMBL12287295 | 0.79 | HSP90AA1 (0.38) | HSP90AA1GAAKDM4ELMNAPAX8 | |
| SCHEMBL8931037 | 0.79 | HSP90AA1 (0.46) | HSP90AA1GAAKDM4ELMNAPAX8 | |
| SCHEMBL13983473 | 0.77 | HPGD (0.40) | HSP90AA1GAAKDM4ELMNAPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037072-A1 | HSP90 INHIBITORS FOR TREATING NON-SMALL CELL LUNG CANCERS IN WILD-TYPE EGFR AND/OR KRAS PATIENTS | SYNTA PHARMACEUTICALS CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2011149824-A1 | CANCER THERAPY USING A COMBINATION OF A HSP90 INHIBITORY COMPOUND AND A TOPOISOMERASE II INHIBITOR | SYNTA PHARMACEUTICALS CORP. (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2008153730-A2 | METHOD FOR TREATING PROLIFERATIVE DISORDERS ASSOCIATED WITH MUTATIONS IN C-MET | SYNTA PHARMACEUTICALS CORP. (US) | 2008-12-18 | — | — | WO | disclosed |