Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GOT1 | P17174 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806553 | 0.94 | HSP90AA1 (0.40) | HSP90AA1GAAKDM4ELMNAPAX8 | |
| SCHEMBL806551 | 0.89 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1 | |
| SCHEMBL12180265 | 0.88 | HSP90AA1 (0.44) | HSP90AA1GAAKDM4ELMNAHSP90AB1 | |
| SCHEMBL8931037 | 0.84 | HSP90AA1 (0.46) | HSP90AA1GAAKDM4ELMNAPAX8 | |
| SCHEMBL13983476 | 0.83 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 | |
| SCHEMBL13983147 | 0.82 | HSP90AA1 (0.43) | HSP90AA1GAAKDM4ELMNAHSP90AB1 | |
| SCHEMBL421133 | 0.79 | HSP90AA1 (0.39) | HSP90AA1GAAKDM4ELMNAPAX8 | |
| SCHEMBL13983105 | 0.78 | HSP90AA1 (0.45) | HSP90AA1GAAKDM4ELMNAPAX8 | |
| SCHEMBL9925250 | 0.77 | GOT1 (0.36) | HSP90AA1GAAMAPTGOT1 | |
| SCHEMBL14933295 | 0.76 | BRD4 (0.38) | HSP90AA1GAAMAPTGOT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013067162-A1 | CANCER THERAPY USING A COMBINATION OF HSP90 INHIBITORS WITH TOPOISOMERASE I INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2013-05-10 | — | — | WO | disclosed |
| WO-2012078757-A2 | COMBINATION BREAST CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011049946-A1 | COMBINATION CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2009075890-A2 | METHOD FOR SYNTHESIS OF TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2009-06-18 | — | — | WO | disclosed |