SCHEMBL8065635

SCHEMBL8065635

O=C(F)C(O)(c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
TSHR P16473 3/20 0.48
HIF1A Q16665 2/20 0.48
MAPK1 P28482 1/20 0.48
MIF P14174 1/20 0.45
CYP19A1 P11511 3/20 0.42
POLB P06746 1/20 0.41
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
ALOX15 P16050 1/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CDC7 O00311 1/20 0.38
PLK4 O00444 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3172134 0.79 CYP2C9 (0.61) MEN1KMT2ATSHRHIF1AMAPK1
Fluoride SCHEMBL9125458 0.77 CYP2C9 (0.59) MEN1KMT2ATSHRHIF1AMAPK1
SCHEMBL29035964 0.77 MIF (0.45) MEN1KMT2ATSHRHIF1AMAPK1
SCHEMBL14166678 0.74 CYP2C9 (0.64) MEN1KMT2ATSHRHIF1AMAPK1
Bromomethane SCHEMBL222144 0.74 CYP2C9 (0.60) MEN1KMT2ATSHRHIF1AMAPK1
SCHEMBL11841428 0.72 MEN1 (0.66) MEN1KMT2ATSHRHIF1AMAPK1
SCHEMBL2860836 0.72 TSHR (0.74) MEN1KMT2ATSHRHIF1AMAPK1
SCHEMBL7434539 0.69 CYP19A1 (0.73) MEN1KMT2ATSHRHIF1AMAPK1
SCHEMBL10764412 0.69 MEN1 (0.62) MEN1KMT2ATSHRHIF1AMAPK1
Chlorobenzilate SCHEMBL73255 0.69 MEN1 (0.60) MEN1KMT2ATSHRMIFPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596395-B1 Process for the preparation of fluorinated benzil CLARIANT GMBH (DE) 2000-06-28 EP disclosed
US-5463135-A Fluorinated benzils and a process for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1995-10-31 US disclosed
EP-0596395-A1 Fluorinated benzils and process for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1994-05-11 EP disclosed