SCHEMBL8065646

SCHEMBL8065646

COc1ccc2cc(-c3ccc(C(F)(F)F)cc3)cc(CCNC(C)=O)c2c1

nearest known ligand 0.75

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 19/20 0.75
MTNR1B P49286 17/20 0.75
HTR2C P28335 2/20 0.60
HTR2B P41595 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6249064 0.90 MTNR1A (0.87) MTNR1AMTNR1BHTR2CHTR2B
SCHEMBL6246366 0.89 MTNR1A (0.74) MTNR1AMTNR1BHTR2CHTR2B
SCHEMBL6246046 0.86 MTNR1A (0.80) MTNR1AMTNR1BHTR2CHTR2B
SCHEMBL6250308 0.86 MTNR1A (0.80) MTNR1AMTNR1BHTR2CHTR2B
SCHEMBL6247733 0.86 MTNR1A (1.00) MTNR1AMTNR1BHTR2CHTR2B
SCHEMBL6142021 0.85 MTNR1A (0.82) MTNR1AMTNR1B
Hydrochloric Acid SCHEMBL8063690 0.85 MTNR1A (0.78) MTNR1AMTNR1BHTR2CHTR2B
SCHEMBL5929481 0.85 MTNR1A (0.79) MTNR1AMTNR1BHTR2C
Hydrochloric Acid SCHEMBL8063736 0.85 MTNR1A (0.78) MTNR1AMTNR1BHTR2CHTR2B
SCHEMBL5929460 0.85 MTNR1A (1.00) MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6143789-A ENANTIOMORPHS ADIR ET COMPAGNIE (FR) 2000-11-07 US disclosed
EP-0919541-A1 Naphthalene compounds, process for their preparation and their pharmaceutical compositions ADIR ET COMPAGNIE (FR) 1999-06-02 EP disclosed