Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058534 | 0.90 | BDKRB1 (0.45) | BDKRB1NPC1ATMMAPK1KMT2A | |
| SCHEMBL15906178 | 0.88 | BDKRB1 (0.44) | BDKRB1NPC1ATMMAPK1KMT2A | |
| SCHEMBL8069544 | 0.86 | BDKRB1 (0.42) | BDKRB1NPC1ATMMAPK1KMT2A | |
| SCHEMBL8065126 | 0.84 | BDKRB1 (0.45) | BDKRB1NPC1ATMMAPK1KMT2A | |
| SCHEMBL10440490 | 0.83 | BDKRB1 (0.41) | BDKRB1NPC1MAPK1KMT2A | |
| SCHEMBL13578463 | 0.83 | BDKRB1 (0.41) | BDKRB1NPC1ATMMAPK1KMT2A | |
| SCHEMBL15906182 | 0.76 | BDKRB1 (0.43) | BDKRB1NPC1MAPK1KMT2AMTNR1A | |
| SCHEMBL15906183 | 0.75 | KMT2A (0.44) | BDKRB1MAPK1KMT2AHTTL3MBTL1 | |
| SCHEMBL8066087 | 0.75 | L3MBTL1 (0.44) | BDKRB1KMT2AHTTL3MBTL1ELANE | |
| SCHEMBL13578460 | 0.74 | BDKRB1 (0.41) | BDKRB1MAPK1KMT2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |