Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067401 | 0.90 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL4323623 | 0.90 | PDE4D (0.43) | HDAC1HDAC8HDAC6CREBBPALDH1A1 | |
| SCHEMBL15906194 | 0.89 | MAOB (0.45) | HDAC1HDAC8HDAC6CREBBPALDH1A1 | |
| SCHEMBL4332990 | 0.88 | CREBBP (0.44) | HDAC1HDAC8HDAC6CREBBPALDH1A1 | |
| SCHEMBL13578678 | 0.85 | POLB (0.39) | HDAC1HDAC8HDAC6CREBBPALDH1A1 | |
| SCHEMBL8056046 | 0.85 | ALDH1A1 (0.38) | CREBBPALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL4326698 | 0.85 | MAOB (0.49) | ALDH1A1MAPTPOLBKMT2AMEN1 | |
| SCHEMBL16158632 | 0.85 | CREBBP (0.37) | HDAC1HDAC8HDAC6CREBBPALDH1A1 | |
| SCHEMBL7916951 | 0.83 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL10318481 | 0.82 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |