Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19696748 | 0.95 | CYP3A4 (0.52) | CYP3A4TDP1ESR1ESR2DRD1 | |
| SCHEMBL7598255 | 0.88 | ESR1 (0.42) | CYP3A4TDP1ESR1ESR2DRD1 | |
| SCHEMBL3076493 | 0.84 | MAPT (0.35) | CYP3A4TDP1MAPTHDAC8 | |
| SCHEMBL10154146 | 0.82 | CYP3A4 (0.44) | CYP3A4TDP1ESR1ESR2DRD1 | |
| SCHEMBL150139 | 0.81 | TDP1 (0.69) | CYP3A4TDP1ESR1ESR2DRD1 | |
| SCHEMBL10154150 | 0.79 | CYP3A4 (0.41) | CYP3A4TDP1ESR1ESR2DRD1 | |
| SCHEMBL8073956 | 0.78 | CYP3A4 (0.65) | CYP3A4TDP1ESR1ESR2DRD1 | |
| SCHEMBL28323816 | 0.78 | CYP3A4 (0.65) | CYP3A4TDP1ESR1ESR2DRD1 | |
| SCHEMBL4146230 | 0.78 | CYP3A4 (0.65) | CYP3A4TDP1ESR1ESR2DRD1 | |
| SCHEMBL29593649 | 0.74 | CYP3A4 (0.58) | CYP3A4TDP1ESR1ESR2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4694085-B2 | — | — | 2011-06-01 | — | — | JP | claimed |
| US-6972320-B2 | Ligation method and reagents to form an amide bond | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2005-12-06 | — | — | US | claimed |
| EP-1399465-B1 | LIGATION METHOD AND REAGENTS TO FORM AN AMIDE BOND | WISCONSIN ALUMNI RES FOUND (US) | 2005-04-13 | — | — | EP | claimed |
| US-20040087779-A1 | Ligation method and reagents to form an amide bond | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-05-06 | — | — | US | claimed |
| EP-1399465-A4 | LIGATION METHOD AND REAGENTS TO FORM AN AMIDE BOND | WISCONSIN ALUMNI RES FOUND (US) | 2004-03-31 | — | — | EP | claimed |
| EP-1399465-A2 | LIGATION METHOD AND REAGENTS TO FORM AN AMIDE BOND | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2004-03-24 | — | — | EP | claimed |
| JP-2004501103-A | — | — | 2004-01-15 | — | — | JP | claimed |
| WO-2001087920-A2 | LIGATION METHOD AND REAGENTS TO FORM AN AMIDE BOND | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2001-11-22 | — | — | WO | claimed |
| CN-108139408-B | Protein retention expansion microscopy | 麻省理工学院 | 2020-08-28 | — | — | CN | disclosed |
| US-10317321-B2 | Protein retention expansion microscopy | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-06-11 | — | — | US | disclosed |
| EP-3332258-A1 | PROTEIN RETENTION EXPANSION MICROSCOPY | Massachusetts Institute of Technology (US) | 2018-06-13 | — | — | EP | disclosed |
| US-20170089811-A1 | Protein Retention Expansion Microscopy | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-30 | — | — | US | disclosed |
| WO-2017027368-A1 | PROTEIN RETENTION EXPANSION MICROSCOPY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-02-16 | — | — | WO | disclosed |
| US-9269913-B2 | Thiolate-bridged multinuclear copper(I) complex | SAMSUNG DISPLAY CO., LTD. (KR) | 2016-02-23 | — | — | US | disclosed |
| EP-1399465-A2 | LIGATION METHOD AND REAGENTS TO FORM AN AMIDE BOND | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2001087920-A2 | LIGATION METHOD AND REAGENTS TO FORM AN AMIDE BOND | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2001-11-22 | — | — | WO | disclosed |
| EP-0632006-B1 | Process for the carbonylation of methanol or a reactive derivative thereof | BP CHEM INT LTD (GB) | 1998-05-13 | — | — | EP | disclosed |
| US-5488153-A | REACTION OF CARBON MONOXIDE IN THE PRESENCE OF RHODIUM CATALYST WITH BIDENTATE PHOSPHOROUS-SULFUR LIGAND AND HALOGEN PROMOTER | BP CHEMICALS LIMITED (GB) | 1996-01-30 | — | — | US | disclosed |
| CN-1105013-A | Process for the carbonylation of methanol or a reactive derivatives thereof | BP CHEM INT LTD (GB) | 1995-07-12 | — | — | CN | disclosed |
| EP-0632006-A1 | Process for the carbonylation of methanol or a reactive derivative thereof | BP Chemicals Limited (GB) | 1995-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087779-A1 | Ligation method and reagents to form an amide bond | PTMS, NAAA, DNPEP | CYP3A4 4364/4885TDP1 3991/4885ESR1 3385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.