Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A11 | Q9UPY5 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PPIA | P62937 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HNF4A | P41235 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058521 | 0.87 | CYP2C9 (0.54) | SLC7A11CYP2C9TSHRMAPK1ALDH1A1 | |
| SCHEMBL8069117 | 0.83 | SLC7A11 (0.66) | SLC7A11CYP2C9TSHRMAPK1ALDH1A1 | |
| SCHEMBL8069115 | 0.83 | SLC7A11 (0.66) | SLC7A11CYP2C9TSHRMAPK1ALDH1A1 | |
| SCHEMBL8068293 | 0.82 | SLC7A11 (0.74) | SLC7A11CYP2C9TSHRMAPK1ALDH1A1 | |
| SCHEMBL8067733 | 0.79 | SLC7A11 (1.00) | SLC7A11CYP2C9TSHRMAPK1ALDH1A1 | |
| SCHEMBL8068591 | 0.77 | SLC7A11 (0.70) | SLC7A11CYP2C9TSHRMAPK1ALDH1A1 | |
| Susalimod SCHEMBL1229340 | 0.77 | SLC7A11 (1.00) | SLC7A11CYP2C9TSHRMAPK1ALDH1A1 | |
| Susalimod SCHEMBL8069177 | 0.76 | SLC7A11 (0.98) | SLC7A11CYP2C9TSHRMAPK1ALDH1A1 | |
| SCHEMBL31469213 | 0.76 | ALDH1A1 (0.73) | CYP2C9TSHRMAPK1ALDH1A1MAPT | |
| SCHEMBL1027519 | 0.73 | TSHR (0.83) | CYP2C9TSHRMAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613468-B1 | Substituted salicylic acids for the treatment of autoimmune diseases | PHARMACIA & UPJOHN AB (SE) | 2000-07-12 | — | — | EP | disclosed |
| CN-1042631-C | Novel substituted salicylic acids | KABI PHARMACIA AB (SE) | 1999-03-24 | — | — | CN | disclosed |
| US-5556855-A | TREATMENT OF AUTOIMMUNE DISEASES | PHARMACIA AB (SE) | 1996-09-17 | — | — | US | disclosed |
| US-5403930-A | Chemical intermediate for drugs used in autoimmune diseases | PHARMACIA AB (SE) | 1995-04-04 | — | — | US | disclosed |
| CN-1088918-A | The salicylic acid compounds of new replacement | KABI PHARMACIA AB (SE) | 1994-07-06 | — | — | CN | disclosed |
| US-5302718-A | Used for treating autoimmune diseases | KABI PHARMACIA AB (SE) | 1994-04-12 | — | — | US | disclosed |