Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.64 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.64 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | PARP1 | P09874 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1258944 | 0.88 | CES2 (0.74) | KCNK3CES2CES1SMN1; SMN2PARP1 | |
| SCHEMBL186545 | 0.88 | PARP1 (0.68) | KCNK3KCNK9SMN1; SMN2PARP1POLB | |
| SCHEMBL29503529 | 0.88 | PARP1 (0.68) | KCNK3KCNK9SMN1; SMN2PARP1POLB | |
| SCHEMBL7811187 | 0.87 | SMN1; SMN2 (0.68) | KCNK3KCNK9SMN1; SMN2PARP1POLB | |
| SCHEMBL15264066 | 0.86 | PARP1 (0.65) | KCNK3KCNK9SMN1; SMN2PARP1POLB | |
| Hydrochloric Acid SCHEMBL27733562 | 0.86 | CES2 (0.71) | KCNK3CES2CES1SMN1; SMN2PARP1 | |
| SCHEMBL2705684 | 0.86 | CES2 (0.71) | KCNK3CES2CES1SMN1; SMN2PARP1 | |
| SCHEMBL822041 | 0.84 | PARP1 (0.63) | KCNK3KCNK9SMN1; SMN2PARP1POLB | |
| SCHEMBL81347 | 0.82 | ATM (0.71) | KCNK3KCNK9SMN1; SMN2PARP1POLB | |
| Bicarbonate SCHEMBL1401812 | 0.82 | CES2 (0.65) | KCNK3CES2CES1SMN1; SMN2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035436-A1 | PLINABULIN PRODRUG ANALOGS AND THERAPEUTIC USES THEREOF | TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES (JP) | 2012-03-22 | — | — | WO | disclosed |