Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 9/20 | 0.49 |
| ▸ | MMP8 | P22894 | 4/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 7/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL489830 | 0.92 | LTB4R2 (0.51) | LTB4R2MMP8LPAR1AGTR1 | |
| SCHEMBL1709602 | 0.92 | LTB4R2 (0.51) | LTB4R2MMP8LPAR1AGTR1 | |
| SCHEMBL13078210 | 0.85 | LTB4R2 (0.50) | LTB4R2MMP8LPAR1AGTR1 | |
| SCHEMBL489273 | 0.82 | LTB4R2 (0.57) | LTB4R2MMP8LPAR1AGTR1 | |
| SCHEMBL1281805 | 0.79 | MMP8 (0.45) | MMP8 | |
| SCHEMBL489832 | 0.79 | MMP8 (0.53) | LTB4R2MMP8AGTR1 | |
| SCHEMBL489265 | 0.78 | MMP8 (0.43) | LTB4R2MMP8AGTR1 | |
| SCHEMBL489263 | 0.78 | MMP8 (0.43) | LTB4R2MMP8AGTR1 | |
| SCHEMBL489488 | 0.78 | MMP8 (0.43) | LTB4R2MMP8AGTR1 | |
| SCHEMBL3653858 | 0.75 | LTB4R2 (0.46) | LTB4R2LPAR1AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009035543-A1 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2009-03-19 | — | — | WO | disclosed |